Salmon DNA facial in Singapore what PDRN is, and what a facial can and cannot do

The basics

What a salmon DNA facial actually is

"Salmon DNA" is the popular name for PDRN (polydeoxyribonucleotide) and PN (polynucleotide). They are mixtures of DNA fragments purified from salmon trout or chum salmon sperm DNA, processed to remove the proteins that could trigger immune reactions. PDRN was first used as a tissue-repair medicine, including for wound healing, before it moved into aesthetics.

A salmon DNA facial puts a cosmetic-grade form of this ingredient on the skin as part of a facial, usually with some way of helping it past the skin's outer layer. That is different from a salmon DNA injection, where a doctor places a professional-grade product into the dermis with a fine needle. Many ads say "salmon DNA" or "Rejuran" without saying which one they mean.

The terms

PDRN, PN, c-PDRN and Rejuran

PDRN and PN are often used interchangeably, which causes confusion. All Rejuran is polynucleotide, but not all PDRN is Rejuran, so check what a treatment actually contains.

How it works

What PDRN is thought to do for skin

Laboratory and clinical research suggests PDRN works mainly by switching on adenosine A2A receptors, which are involved in tissue repair and in calming inflammation. It also supplies building blocks that cells can reuse when making DNA, known as the salvage pathway.

In skin terms, that means support for fibroblasts, the cells that make collagen, and for hydration and barrier recovery. This is why polynucleotides are used for dull or dehydrated skin, fine lines, sensitised skin and skin recovering from procedures. It is a skin-quality ingredient: it does not lift, add volume or remove pigment.

Injected vs needle-free

Injected PDRN vs a needle-free facial

These routes are not substitutes for one another. Injection reaches deeper and does more, with more downtime; a facial is gentler, needs no needles and suits people who want gradual change or maintenance.

Evidence

What the evidence shows, and what it does not

For injections, a 2025 systematic review found nine studies of low to moderate quality, covering 219 patients. Results for wrinkles, texture and elasticity were promising and side effects mostly mild and short-lived, but the authors called for more rigorous trials. A 2026 expert panel, whose authors included advisers to and employees of a polynucleotide manufacturer, reported no published cases of granuloma or blocked vessels, and also described the evidence base as limited.

For topical use, the evidence is weaker. Intact skin lets very little through above about 500 daltons, and PDRN fragments are roughly 100 to 3,000 times larger. One small 2026 randomised split-face study of 31 women found a 0.1% PDRN eye cream improved fine lines and skin density over 28 days compared with a retinol cream, which is encouraging but is one product, one short study and a cream rather than a facial.

We found no published studies on the Meso Touch device itself, and evidence for injections does not transfer directly to a facial. So we describe a PDRN facial as a gradual, course-based improvement in hydration, calmness and texture, not as an injection without the needle. Results vary.

At SkinRev Lab

The Rejuran PDRN Facial: nine tiers

Every tier is built around the same needle-free Rejuran c-PDRN infusion from the Rejuran Professional range, delivered with Meso Touch transdermal technology. What changes is the technique around it and the session length: the Singapore range is massage-led, the Oriental range uses pressure-point massage or guasha, and the Korea range is infusion-led, adding boosters, galvanic or LED, with a scalp tier.

Longer tiers add steps such as clogged-pore care, extraction, shoulder massage and double masking. No first-visit rate is published for this facial. Your Aesthetic Specialist suggests a starting tier at a skin assessment at CityLink Mall #B1-28, by City Hall MRT.

Choosing

Who suits a facial, and who should consider injection

On public Singapore clinic pages we checked in October 2026, injected polynucleotide boosters were advertised from about S$500 to S$700, and one Singapore doctor-answer site quoted about S$600 to S$1,400 a session for Rejuran Healer. At IN Eternity Clinic, Dr Sin Yong performs injectable PN, HA and PDLLA boosters, priced at consultation by the clinic; WhatsApp +65 8815 3008.

• A needle-free PDRN facial suits dull, dehydrated or reactive skin, people who want no needles and no recovery time, and maintenance between other treatments.
• Injected polynucleotides suit people who want a stronger skin-quality change, such as crepey under-eyes, and accept small bumps and possible bruising.
• Deep or pitted acne scars usually need more than either: resurfacing or a combined scar plan with a doctor.
• Sagging, hollows and pigment need other treatments; PDRN does not lift, fill or remove spots.

Safety

Safety, and when to see a doctor first

• Tell your provider about any fish or salmon allergy, as PDRN is derived from fish DNA.
• Injected boosters are not advised during pregnancy or breastfeeding, or over infection, cold sores or inflamed acne.
• Only a doctor should inject polynucleotides. If an injection is offered by someone who is not a doctor, do not go ahead.
• See a doctor first for painful or scarring acne, a rash that keeps flaring, or any spot that is new, changing or bleeding.
• Tell each provider about recent injections or lasers, so facials are not booked too soon afterwards.

Sources

References & sources

1. Squadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017;8:224.
2. Marques C, Porcello A, Cerrano M, et al. From polydeoxyribonucleotides (PDRNs) to polynucleotides (PNs): bridging the gap between scientific definitions, molecular insights, and clinical applications of multifunctional biomolecules. Biomolecules. 2025;15(1):148.
3. Lampridou S, Bassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(2):e16721.
4. Rho NK, Chilukuri S, Chan G, et al. Expert perspectives: evidence-based applications of polynucleotides (PNs) in aesthetic medicine and dermatology. Clin Cosmet Investig Dermatol. 2026;19:557226.
5. Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000;9(3):165-169.
6. Ye R, Wang Q, Du L, Li L, Hu F. Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K-Akt/TGF-beta-regulated pathways. PLoS One. 2026;21(7):e0350905.

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