Medical treatment · Skin boosters
Nucleofill in Singapore: the polynucleotide skin booster, by Dr Sin Yong
Nucleofill is a polynucleotide booster: purified DNA fragments placed in the skin to support repair, especially in thin, crepey skin under the eyes. At SkinRev Lab, CityLink Mall, Dr Sin Yong assesses your skin first and performs it himself. Here is what it can do, what it cannot, and how a course works.
By Dr Sin Yong · Updated 9 Nov 2026
In short
Nucleofill is an Italian polynucleotide (PN) skin booster: purified DNA fragments injected in small amounts to support repair and improve thin, crepey skin, fine lines and texture, including under the eyes. It is not a filler and adds no volume. At SkinRev Lab, CityLink Mall, Dr Sin Yong assesses first and performs it himself.
Key facts
- Performed by: Dr Sin Yong, at SkinRev Lab, #B1-28 CityLink Mall (City Hall MRT)
- Course: Usually a few sessions a few weeks apart, then maintenance; the number is set at consultation
- Downtime: Small bumps, redness and possible bruising for a day or two
- Price: Priced at consultation, after assessment
Quick answer
- Nucleofill is a brand of polynucleotide (PN) skin booster from Italy, with versions for the face, the under-eye area and the body at different concentrations.
- Polynucleotides are purified DNA fragments, mostly from fish, that support the skin's own repair. They improve thin, crepey skin, fine lines and texture; they do not lift or add volume.
- The evidence for polynucleotides is promising but limited: small trials, mostly around the eyes, with mild side effects.
- At SkinRev Lab, CityLink Mall, Dr Sin Yong performs Nucleofill after assessing your skin; it is priced at consultation.
General information only, not medical advice. Your own suitability is assessed at consultation.
What it is
What Nucleofill is
Nucleofill is a polynucleotide (PN) skin booster. Polynucleotides are long chains of purified DNA fragments, mostly from fish, with the proteins removed. Injected in small amounts into the skin, they are thought to support the cells that repair and renew it, which is why PN boosters are used for thin, crepey and tired-looking skin.
The range includes versions for the face, a softer version for the under-eye area and versions for the body, at different concentrations. Dr Sin Yong chooses the version for the area, and the product is named and recorded at your visit. For how PN differs from PDRN, see polynucleotides (PN) vs PDRN.
Who it suits
What Nucleofill can and cannot do
- Can help: crepey skin under the eyes, fine lines, rough texture, thin skin on the neck and skin that looks tired after sun or stress.
- Cannot do: fill a hollow tear trough, lift sagging skin or change face shape. A hollow needs filler; sagging needs lifting or tightening.
- Wait if: you are pregnant or breastfeeding, have an active skin infection or a flare of a skin condition in the area, or have a known allergy to fish or salmon products (discuss first).
Comparison
Nucleofill vs other skin boosters
| Booster | What it is | Mainly used for | Adds volume? |
|---|---|---|---|
| Nucleofill | Polynucleotides (PN) in versions for face, eyes and body | Thin, crepey skin; under-eye texture | No |
| Rejuran | Polynucleotides (PN) | Skin repair and texture | No |
| HA skin booster | Non- or lightly cross-linked hyaluronic acid | Hydration, fine lines | No |
| Chanel injection (NCTF 135HA) | Non-cross-linked HA with vitamins and amino acids | Glow, hydration | No |
| Tear trough filler | Cross-linked HA gel | Filling a hollow | Yes |
Lampridou S, et al. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(2):e16721. Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260.
More: Chanel injection, skin boosters and tear trough filler.
At SkinRev Lab
How Nucleofill is done at SkinRev Lab
- Assessment: Dr Sin Yong examines the area, asks about allergies, medicines and earlier treatments, and explains whether PN, another booster or a different treatment fits better.
- Session: numbing cream, then small amounts placed into the skin as droplets or fine lines; around the eyes this is done with care in thin skin.
- Course: usually a few sessions a few weeks apart, then maintenance; the number is set at consultation.
- Afterwards: small bumps and redness settle within a day or two; bruising is possible, especially under the eyes.
The evidence
What the evidence shows
A 2025 systematic review of polynucleotides in aesthetic medicine found nine studies of low to moderate quality covering 219 patients, with promising results for wrinkles, texture and elasticity and mostly mild side effects. A randomised split-face trial found PN performed similarly to a non-cross-linked HA booster around the eyes. Brand-specific trials are few, so expectations should be modest and results vary.
Book
Nucleofill at SkinRev Lab, CityLink
Nucleofill is performed by Dr Sin Yong at SkinRev Lab after he assesses your skin, and it is priced at consultation. SkinRev Lab, #B1-28 CityLink Mall, 1 Raffles Link, linked underground to City Hall and Esplanade MRT. Open daily 11am to 8pm. WhatsApp +65 8266 9585.
Evidence
References & sources
- Lampridou S, et al. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(2):e16721.
- Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260.
- Rho NK, et al. Expert perspectives: evidence-based applications of polynucleotides (PNs) in aesthetic medicine and dermatology. Clin Cosmet Investig Dermatol. 2026.
- Rho NK, Kim HS, Kim SY, Lee W. Injectable 'skin boosters' in aging skin rejuvenation: a current overview. Arch Plast Surg. 2024;51(6):528-541.
Common questions
Your questions,
answered
What is Nucleofill?
A polynucleotide (PN) skin booster: purified DNA fragments injected in small amounts to support repair and improve thin, crepey skin, fine lines and texture. It is not a volumising filler.
Does SkinRev Lab offer Nucleofill in Singapore?
Yes. Dr Sin Yong performs Nucleofill at SkinRev Lab, CityLink Mall, after assessing your skin. It is priced at consultation.
Is Nucleofill the same as Rejuran?
Both are polynucleotide boosters made from purified DNA fragments, but they are different brands with different formulations and concentrations. Neither adds volume.
Can Nucleofill be used under the eyes?
Yes, there is a softer version for the under-eye area. It improves crepey skin and fine lines; it does not fill a hollow tear trough.
How many Nucleofill sessions are needed?
Usually a few sessions a few weeks apart, then maintenance. The number depends on your skin and is set at consultation.
Is Nucleofill a filler?
No. It works on skin quality and does not add volume or change face shape.